Key Autism Research

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Hyperbaric Oxygen Therapy (HBOT) Research for Autism.

Hyperbaric treatment for children with autism: a multicenter, randomized, double-blind, controlled trial.

Several uncontrolled studies of hyperbaric treatment in children with autism have reported clinical improvements; however, this treatment has not been evaluated to date with a controlled study. We performed a multicenter, randomized, double-blind, controlled trial to assess the efficacy of hyperbaric treatment in children with autism. 62 children with autism recruited from 6 centers, ages 2-7 years (mean 4.92 +/- 1.21), were randomly assigned to 40 hourly treatments of either hyperbaric treatment at 1.3 atmosphere (atm) and 24% oxygen (“treatment group”, n = 33) or slightly pressurized room air at 1.03 atm and 21% oxygen (“control group”, n = 29). Outcome measures included Clinical Global Impression (CGI) scale, Aberrant Behavior Checklist (ABC), and Autism Treatment Evaluation Checklist (ATEC).

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Abnormal EEG lateralization in boys with autism

Abnormal EEG lateralization in boys with autism

Abstract Objective: Functional brain abnormalities associated with autism in 3-8-year-old boys were studied with EEG recorded under controlled experimental condition of sustained visual attention and behavioral stillness. Methods: EEG was recorded in two independent...

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Hyperbaric oxygen therapy might improve certain pathophysiological findings in autism.

Autism is a neurodevelopmental disorder currently affecting as many as 1 out of 166 children in the United States. Numerous studies of autistic individuals have revealed evidence of cerebral hypoperfusion, neuroinflammation and gastrointestinal inflammation, immune dysregulation, oxidative stress, relative mitochondrial dysfunction, neurotransmitter abnormalities, impaired detoxification of toxins, dysbiosis, and impaired production of porphyrins. Many of these findings have been correlated with core autistic symptoms. For example, cerebral hypoperfusion in autistic children has been correlated with repetitive, self-stimulatory and stereotypical behaviors, and impairments in communication, sensory perception, and social interaction.

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