Abstract: The prevention of osteoradionecrosis of the jaws (ORNJ) is very important because of the current absence of effective therapies for this disease. The aim of this study was to determine whether low-intensity ultrasound has a preventive effect on ORNJ. Sixty...
Cancer
Hyperbaric Oxygen Therapy (HBOT) Research for Cancer.
Lung cancer screening with low-dose computed tomography: Experiences from a tertiary hospital in Taiwan.
Abstract: Lung cancer screening using low-dose computed tomography (CT) has been reported to reduce lung cancer-specific mortality for smokers at high risk. However, despite different characteristics of lung cancer in Asia, there are few data concerning this specific...
An Adverse Implication of Radiation Therapy for Implant-Retained Maxillofacial Prostheses.
Abstract: We report the 19-year postoperative course of a patient whose maxillary defect was reconstructed with maxillofacial implant-retained facial prostheses. The patient received 60 Gy of radiation therapy. Adjunctive hyperbaric oxygen therapy was administered and...
Thoracic spinal anesthesia is safe for patients undergoing abdominal cancer surgery.
Abstract: A double-blinded randomized controlled study to compare discharge time and patient satisfaction between two groups of patients submitted to open surgeries for abdominal malignancies using segmental thoracic spinal or general anesthesia. Open surgeries for...
The therapeutic effect of photon irradiation on viable glioblastoma cells is reinforced by hyperbaric oxygen.
Abstract: Hyperbaric oxygen (HBO) seems to intensify the effect of ionising radiation. We investigated whether HBO combined with irradiation decreases the capability of U251 glioblastoma cells for relapse and metastasis. Cells were treated with O2 at 1.3 bar and then...
Spatial oxygenation profiles in tumors during normo- and hyperbaric hyperoxia.
Abstract: Inspiratory hyperoxia reduces tumor hypoxia, which is responsible for limited radiosensitivity of tumors. However, very little is known about the heterogeneity of intratumoral oxygenation during this supportive treatment. The study analyzes whether local...
Successful treatment for sorafenib-induced liver dysfunction: a report of case with liver biopsy.
Abstract: Sorafenib is an oral multikinase inhibitor with anti-proliferative and anti-angiogenic effects and is used worldwide for the treatment of advanced or metastatic hepatocellular carcinoma (HCC). While the significant survival benefit of sorafenib in patients...
Molecular mechanisms of pharmacological doses of ascorbate on cancer cells.
Abstract: Intravenous application of high-dose ascorbate (vitamin C) has been used in complementary medicine since the 1970s to treat cancer patients. In recent years it became evident that high-dose ascorbate in the millimolar range bears selective cytotoxic effects...
Pentoxifylline-tocopherol-clodronate combination: A novel treatment for osteoradionecrosis of the temporal bone.
Abstract: Osteoradionecrosis (ORN) of the temporal bone is a complication of radiation therapy that is extremely challenging to manage. We report the case of a patient treated at our institution and present a review of the literature. A 52-year-old woman presented...