Abstract: Calcific uraemic arteriolopathy (CUA), also known as 'calciphylaxis', is a syndrome of ischaemic necrotic ulcers occurring in uraemic patients with end-stage renal failure. It is a debilitating condition with a high morbidity and mortality. Hyperbaric oxygen...
Chronic Heart Failure
Hyperbaric Oxygen Therapy (HBOT) Research for Chronic Heart Failure.
Hyperbaric oxygen: a novel technology for modulating myocardial schemia-reperfusion via a single drug.
Abstract: Over the years, the anecdotal medical use of oxygen has demonstrated, in a non-evidence-based manner, that it may have wide-ranging clinical consequences. Although oxygen is a critical substrate in the alleviation of hypoxia, anoxia, and ischemia,...
Effect of hyperbaric oxygen on cardiac neural regulation in diabetic individuals with foot complications.
Abstract: There are relatively few effective methods to treat autonomic neuropathy in patients with diabetes mellitus. Our aim was to test the hypothesis that hyperbaric oxygen therapy may restore cardiac neural regulation dysfunction in diabetic individuals with foot...
Clinical observation: Beau’s lines on fingernails after deep saturation dives.
Abstract: Transverse furrows, or Beau's lines, were noted in the fingernails of all 6 divers following a deep saturation dive to apressure equal to 1100 feet (335 meters) ofsea water (3,370 kPa), and in 2 of6 divers following a similar dive to 1000 feet (305 meters)...
Hyperbaric oxygen: a new drug in myocardial revascularization and protection?
Abstract: Ischemia-reperfusion injury (IRI) occurs following coronary artery revascularization. Reactive oxygen species (ROS) were initially thought to play a role in the pathogenesis of this injury. However, the evidence for this is inconclusive. Recent studies...
Myocardial injury and long-term mortality following moderate to severe carbon monoxide poisoning.
Abstract: Carbon monoxide (CO) poisoning is a common cause of toxicological morbidity and mortality. Myocardial injury is a frequent consequence of moderate to severe CO poisoning. While the in-hospital mortality for these patients is low, the long-term outcome of...
Carbon monoxide poisoning: a five year review at Tan Tock Seng Hospital, Singapore.
Abstract: Carbon monoxide poisoning (COP) is one of the leading causes of death from poisoning worldwide. There is no published study of COP in Singapore so far. All patients admitted with the diagnosis of COP to Tan Tock Seng Hospital (TTSH) over 5 years from 1999 to...
Acute Myocardial Infarction with Hyperoxemic Therapy (AMIHOT): a prospective, randomized trial of intracoronary hyperoxemic reperfusion after percutaneous coronary intervention.
Abstract: This study sought to determine whether hyperoxemic reperfusion with aqueous oxygen (AO) improves recovery of ventricular function after percutaneous coronary intervention (PCI) for acute myocardial infarction (AMI). Hyperbaric oxygen reduces myocardial...
Hyperoxic and hyperbaric-induced cardioprotection: role of nitric oxide synthase 3.
Abstract: The relative contributions of the fraction of inspired oxygen (FIO2) and atmospheric pressure (ATM) to cardioprotection are unknown. We determined whether the product of FIO2 x ATM (oxygen partial pressure) controls the extent of hyperoxic+hyperbaric-induced...