Abstract: Cancer patients who undergo radiotherapy remain at life-long risk of radiation-induced injury to normal tissues. We conducted a randomized, controlled, double-blind crossover trial with long-term follow-up to evaluate the effectiveness of hyperbaric oxygen...
Chronic Wounds
Hyperbaric Oxygen Therapy (HBOT) Research for Chronic Wounds.
alpha-Lipoic acid modulates extracellular matrix and angiogenesis gene expression in non-healing wounds treated with hyperbaric oxygen therapy.
Abstract: alpha-Lipoic acid (LA) has been found previously to accelerate wound repair in patients affected by chronic wounds who underwent hyperbaric oxygen (HBO) therapy. Because proteinases are important in wound repair, we hypothesized that LA may regulate matrix...
Using angiogenesis in chronic wound care with becaplermin and oxidized regenerated cellulose/collagen.
Abstract: For most of the last century, chronic wound care was a practice of passive techniques, designed to prevent the progression of the wound. In the last decade, however, advanced techniques have focused on improving the wound at the molecular level to accelerate...
Hyperbaric oxygenotherapy as a possible means of preventing ischemic changes in skin grafts used for soft tissue defect closure.
Abstract: The Center of Hyperbaric Oxygenotherapy was established in September 2001 and started to provide hyperbaric treatment services for patients suffering from chronic, non-healing soft tissue defects in close cooperation with the Department of Plastic,...
Hyperbaric oxygen therapy mediates increased nitric oxide production associated with wound healing: a preliminary study.
Abstract: The objective of this preliminary study was to document general somatic and wound nitric oxide (NO) levels during and after hyperbaric oxygen therapy (HBOT). The study evaluated 6 chronic wound patients that responded favorably to HBOT treatment (20...
Osteoradionecrosis of external auditory canal in nasopharyngeal carcinoma.
Abstract: Osteoradionecrosis (ORN) is one of the most serious complications of radiotherapy of nasopharyngeal carcinoma (NPC). ORN rarely occurs in the external auditory canal. This is a retrospective review of 11 NPC patients who had ORN in the external auditory...
Treatment of radiation proctitis.
Abstract: Late complications of pelvic radiotherapy occur in 5-20% of patients, particularly chronic radiation proctitis (CRP). Rectal bleeding is the most common symptom. Other symptoms include difficulty in defaecation or tenesmus because of loss of distensibility...
Treatment of gastrointestinal radiation injury with hyperbaric oxygen.
Abstract: Chronic radiation enteritis develops in 5-20% of patients following abdominal and pelvic radiation. Current treatments are largely ineffective. To assess the effectiveness of hyperbaric oxygen therapy (HBO2) as a treatment for chronic radiation enteritis and...
Current management for late normal tissue injury: radiation-induced fibrosis and necrosis.
Abstract: Radiation-induced fibrosis (RIF) and radionecrosis (RN) are late complications that are usually considered irreversible. Usual management strategy includes eliminating local and general aggravating factors and controlling acute and chronic inflammation with...