Abstract: BACKGROUND: Disrupted vasculature and high energy-demand to support processing and regeneration of wounded tissue are typical characteristics of a wound site. Oxygen delivery is a critical element for the healing of wounds. Clinical experience with...
Chronic Wounds
Hyperbaric Oxygen Therapy (HBOT) Research for Chronic Wounds.
Intractable livedoid vasculopathy successfully treated with hyperbaric oxygen.
Abstract: We describe a new method for treating livedoid vasculopathy. The typical presentation of livedoid vasculopathy includes chronic, recurrent painful ulcers, satellite scar-like atrophy and telangiectasia involving the lower extremities. Histologically, these...
Promoting healing with recombinant human platelet-derived growth factor–BB in a previously irradiated problem wound.
Abstract: Persistent, poorly healing wounds are a significant clinical problem in patients who have had previous irradiation. Despite current treatments, refractory nonhealing soft tissue wounds persist. The study described one of the earliest reported uses of...
Radiotherapy-induced ear toxicity.
Abstract: Despite their particular functional consequences, radiotherapy-induced ear injuries remain under-evaluated and under-reported. These reactions may have acute or late character, may affect all structures of the hearing organ, and result in conductive,...
Revisiting the essential role of oxygen in wound healing.
Abstract: Hypoxemia, caused by disrupted vasculature, is a key factor that limits wound healing. Correcting hypoxemia through the administration of supplemental oxygen (O(2)) can have significant beneficial impact on wound healing in the perioperative and outpatient...
The influence of nonsteroidal anti-inflammatory drugs abuse and chronic stress on the development of necrotizing fasciitis–case report.
Abstract: In this report we present the case of a 19-year-old woman who was admitted to hospital due to an intense pain of the left gluteofemoral region and the symptoms of toxic shock. For 5 days before admission to hospital the patient had a strong pain and fever,...
A review of mechanical adjuncts in wound healing: hydrotherapy, ultrasound, negative pressure therapy, hyperbaric oxygen, and electrostimulation.
Abstract: Chronic or non-healing wounds may develop in the setting of many diseases and are the source of considerable morbidity as well as health costs. These wounds demand an aggressive, multifactorial approach including surgical debridement, revascularization,...
Ischemic wound healing and possible treatments.
Abstract: The present review describes the major steps in wound healing, the factors that clinically cause ischemia including the changes found in diabetes mellitus and the possible interventions and treatments of ischemic wounds. The number of randomized,...
Simple approach to the radiated scalp wound using INTEGRA skin substitute.
Abstract: The chronic irradiated scalp wound remains one of the most difficult reconstructions for the plastic surgeon. With its inherent radiodermatitis and poor healing potential, chronic ulcers down to bone will result if coverage cannot be achieved. Reconstructive...