Abstract: Spleen tyrosine kinase (SYK) has an important role in immunoreceptor signaling, and SYK inhibition has accordingly attenuated immune-mediated injury in several models. Therefore, the present study examined the effect of SYK inhibition with the selective...
Rheumatoid Arthritis
Hyperbaric Oxygen Therapy (HBOT) Research for Rheumatoid Arthritis
Chronic Leg Ulcers in Adult Patients with Rheumatological Disease, A 7-Year Retrospective Review
Chia HY, Tang MB. Chronic leg ulcers in adult patients with rheumatological disease, a 7-year retrospective review. Int. Wound 2014; 11(6):601-4. doi:10.111/jwj.12012. Epub 2012 Dec 12.
Acquiring the optimal time for hyperbaric therapy in the rat model of CFA induced arthritis.
Abstract: We previously published an article about the pressure effect using a rheumatoid animal model. Hyperbaric therapy appears to be beneficial in treating rheumatoid arthritis (RA) by reducing the inflammatory process in an animal model. In this sense, acquiring...
Effects of low-intensity pulsed ultrasound and hyperbaric oxygen on human osteoarthritic chondrocytes.
Abstract: Although the individual effects of hyperbaric oxygen (HBO) and low-intensity pulsed ultrasound (LIPUS) on osteoarthritic (OA) chondrocytes have been reported, the effects of HBO combined with LIPUS treatment are unknown. OA chondrocytes were obtained from...
Bone and joint infections due to anaerobic bacteria: an analysis of 61 cases and review of the literature.
Abstract: The diagnosis of anaerobic bone and joint infections (BJI) were underestimated before the advent of molecular identification and matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS). We report 61 cases of anaerobic...
The effects of pressure on arthritic knees in a rat model of CFA-induced arthritis.
Abstract: Pain is influenced by weather changes under certain circumstances, and inflammatory pain in animal models is ameliorated by pressure, but the underlying mechanism of atmospheric pressure has not been clearly elucidated. To examine the effect of pressure on...
Effect of high dose intravenous ascorbic acid on the level of inflammation in patients with rheumatoid arthritis
Abstract Rheumatoid arthritis (RA) is a major inflammatory joint disease that causes cartilage destruction , bone erosions, and joint destruction. Oxidative stress is elevated in RA patients implying reactive oxygen species (ROS) are possible mediators of tissue...
Hyperbaric oxygen – its mechanisms and efficacy
Principal mechanisms of HBO2 are based on intracellular generation of reactive species of oxygen and nitrogen. Reactive species are recognized to play a central role in cell signal transduction cascades and the discussion will focus on these pathways. Systematic reviews and randomized clinical trials support clinical use of HBO2 for refractory diabetic wound healing and radiation injuries; treatment of compromised flaps and grafts and ischemia-reperfusion disorders is supported by animal studies and a small number of clinical trials, but further studies are warranted.
[Optimization of the treatment of patients with osteoarthrosis using hyperbaric gaseous cryotherapy].
Abstract: The authors report the results of combined rehabilitative treatment of patients presenting with gonarthrosis and coxarthrosis by means of hyperbaric cryotherapy using carbon dioxide at -78 degrees C. Estimation of the data obtained based on the...