Abstract In patients with Crohn's Disease (CD), malnutrition is frequently observed and is an important complication, frequently associated with nutritional deficiencies, especially vitamins (both water- and fat-soluble) and essential trace elements. It is often a...
Intravenous Therapy Research
The inflammatory response in the pathogenesis of asthma
Ishmael, Faoud. (2011). The inflammatory response in the pathogenesis of asthma. The Journal of the American Osteopathic Association. 111. S11-7.
Atopy, asthma, and lung function in relation to folate and vitamin B(12) in adults
Abstract Background: Recent studies suggested low serum folate and impaired folate metabolism as potential risk factors for development of asthma and atopic disease, but the results are inconsistent. The aim of this study was to investigate the relations of markers of...
Effects of high-dose B vitamin complex with vitamin C and minerals on subjective mood and performance in healthy males
Abstract Rationale: A significant proportion of the general population report supplementing their diet with one or more vitamins or minerals, with common reasons for doing so being to combat stress and fatigue and to improve mental functioning. Few studies have...
Vitamin B12 in health and disease
Abstract Vitamin B(12) is essential for DNA synthesis and for cellular energy production.This review aims to outline the metabolism of vitamin B(12), and to evaluate the causes and consequences of sub-clinical vitamin B(12) deficiency. Vitamin B(12) deficiency is...
Glutathione: overview of its protective roles, measurement, and biosynthesis
Abstract This review is the introduction to a special issue concerning, glutathione (GSH), the most abundant low molecular weight thiol compound synthesized in cells. GSH plays critical roles in protecting cells from oxidative damage and the toxicity of xenobiotic...
The central role of glutathione in the pathophysiology of human diseases
Abstract Reduced glutathione (L-gamma-glutamyl-L-cysteinyl-glycine, GSH) is the prevalent low-molecular-weight thiol in mammalian cells. It is formed in a two-step enzymatic process including, first, the formation of gamma-glutamylcysteine from glutamate and cysteine,...
The role of TNF-alpha in chronic inflammatory conditions, intermediary metabolism, and cardiovascular risk
Abstract The recent insight that inflammation contributes to the development of atherosclerosis and type 2 diabetes mellitus constitutes a major breakthrough in understanding the mechanisms underlying these conditions. In addition, it opens the way for new therapeutic...
Thoughts on B-vitamins and dementia
Abstract The B-vitamins, including vitamins B12, B6, B1, B2, niacin (B3) and folate (B9), have been implicated as protective risk factors against cognitive decline and Alzheimer's disease. This commentary reviews the evidence to support protective relations of these...