Rheumatoid Arthritis

Rheumatoid Arthritis (RA) is an autoimmune disease that causes severe joint pain, stiffness, and swelling (1). Although the exact pathology of RA remains unclear, the root cause of RA symptoms is inflammation of the joints, most commonly joints in the hands and feet (2). Current treatment for RA consists of medications such as nonsteroidal anti-inflammatory drugs (NSAIDs), steroids, disease-modifying antirheumatic drugs (DMARDSs), and biologic agents (3). The main target for all these drugs is inflammation reduction, but each drug has many potential side effects including heart, kidney, and liver damage, increased risk of infection, and stomach issues(3, 4).

 

Extivita Therapies for Rheumatoid Arthritis:

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Extivita Therapies for Rheumatoid Arthritis:

Hyperbaric Oxygen Therapy

Hyperbaric Oxygen Therapy

Hyperbaric Oxygen Therapy

Neurofeedback

Hyperbaric Oxygen Therapy

Supplements

Hyperbaric Oxygen Therapy

Nutritional IV Therapy

Pulsed Electromagnetic Field Therapy (PEMF)

Pulsed Electromagnetic Field Therapy

Hyperbaric Oxygen Therapy for Rheumatoid Arthritis:

Hyperbaric Oxygen Therapy - Chapel Hill
Hyperbaric oxygen therapy (HBOT) is one of the safest available therapies and is proven to reduce systemic inflammation, suggesting its potential use for RA treatment (5,6,7). HBOT has repeatedly been shown to reduce the specific pro-inflammatory cytokines that are known to cause inflammation in RA (8, 9, 10). These cytokines include tumor necrosis factor alpha (TNFα), Il-1, and IL-6 all of which contribute to joint inflammation and cartilage destruction (11). Specific studies on HBOT and RA are limited but have found that HBOT can reduce joint pain, increase activity level, and improve sleeping in those with RA (12).
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Effects of HBOT on Rheumatoid Arthritis:

Decreases Inflammation

Decreased Inflammation

Hyperbaric oxygen therapy reduces systemic inflammation by increasing anti-inflammatory gene expression and decreasing proinflammatory genes.
Increases Stem Cell Production

Increased Stem Cell Activity

Hyperbaric oxygen therapy mobilizes stem progenitor cells (SPCs) from the bone marrow, creating the opportunity for tissue regeneration.
Grows New Blood Vessels

New Blood Vessel Formation

Hyperbaric oxygen therapy stimulates the formation of new blood vessels, healing injured tissues that were unable to get nutrients and oxygen.
Hyperbaric Oxygen Therapy - Chapel Hill

Neurofeedback for Rheumatoid Arthritis:

According to research, RA symptoms can worsen due to the emotional distress from living with a chronic illness. Studies have also shown that the brain and the immune system are linked, therefore neurofeedback (NF) may have the potential to reduce RA symptoms (13). More specifically, NF training can help repair neural connectivity and thus support immune system function. In addition, NF training has been shown to reduce psychological/emotional factors such as stress, anxiety, depression that accompany RA, thereby reducing medication regimen and improving quality of life (14).

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IV Therapy for Rheumatoid Arthritis:

The development of RA has been shown to involve excessive free radical formation and a compromised antioxidant system (15). Intravenous micronutrient therapy, like the Myers cocktail and High Dose Vitamin C, can protect cells from damage by free radicals and reactive oxygen species and support collagen formation (16).

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Hyperbaric Oxygen Therapy - Chapel Hill
BEMER Pulsed Electromagnetic Field Therapy in Durham, NC

Pulsed Electromagnetic Field Therapy for Rheumatoid Arthritis:

Rheumatoid arthritis patients have been shown to have endothelial dysfunction. Endothelial dysfunction ultimately leads to impaired microcirculation, increasing the RA patient’s risk of cardiovascular disease (17). Pulsed electromagnetic therapy is a safe, non-invasive method that can reduce vascular dysfunctions, protect joints, and alleviate pain and inflammation related to RA (18).

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News & Research for for Rheumatoid Arthritis:

Hyperbaric oxygen treatment is comparable to acetylsalicylic acid treatment in an animal model of arthritis.

Hyperbaric oxygen treatment is comparable to acetylsalicylic acid treatment in an animal model of arthritis.

Apr 14, 2007 | , ,

Approximately 1 in 5 adults in the United States are affected by the pain, disability, and decreased quality of life associated with arthritis. The primary focus of treatment is on reducing joint inflammation and pain through a variety of pharmacotherapies, each of which is associated with various side effects. Hyperbaric oxygen therapy is an alternative treatment that has been recommended to treat a variety of inflammatory diseases, ranging from chronic brain injury to exercise induced muscle soreness. The purpose of this set of experiments was to explore the effect of hyperbaric oxygen therapy on joint inflammation and mechanical hyperalgesia in an animal model of arthritis, and compare these effects to treatment with aspirin. Hyperbaric oxygen therapy significantly reduced both joint inflammation and hyperalgesia. As compared with aspirin treatment, hyperbaric treatment was equally as effective in decreasing joint inflammation and hyperalgesia. This article reports that hyperbaric oxygen treatment decreases pain and inflammation in an animal model of arthritis. The effect of hyperbaric oxygen treatment is very similar in magnitude to the effect of acetylsalicylic acid treatment. Potentially, hyperbaric oxygen could be used to treat pain and inflammation in patients with arthritis.

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References
  1. Diseases and Conditions Rheumatoid Arthritis. https://www.rheumatology.org/I-Am-A/Patient-Caregiver/Diseases-Conditions/Rheumatoid-Arthritis. Accessed 23 July 2020.
  2. Zhang, Angela, and Yvonne C. Lee. “Mechanisms for Joint Pain in Rheumatoid Arthritis (RA): From Cytokines to Central Sensitization.” Current Osteoporosis Reports, vol. 16, no. 5, Oct. 2018, pp. 603–10. PubMed Central, doi:10.1007/s11914-018-0473-5.
  3. Rheumatoid Arthritis – Diagnosis and Treatment – Mayo Clinic. https://www.mayoclinic.org/diseases-conditions/rheumatoid-arthritis/diagnosis-treatment/drc-20353653. Accessed 23 July 2020.
  4. Benjamin, Onecia, et al. “Disease Modifying Anti-Rheumatic Drugs (DMARD).” StatPearls, StatPearls Publishing, 2020. PubMed, http://www.ncbi.nlm.nih.gov/books/NBK507863/.
  5. Heyboer, Marvin, et al. “Hyperbaric Oxygen Therapy: Side Effects Defined and Quantified.” Advances in Wound Care, vol. 6, no. 6, June 2017, pp. 210–24. PubMed Central, doi:10.1089/wound.2016.0718.
  6. Thom, Stephen R. “Hyperbaric Oxygen – Its Mechanisms and Efficacy.” Plastic and Reconstructive Surgery, vol. 127, no. Suppl 1, Jan. 2011, pp. 131S-141S. PubMed Central, doi:10.1097/PRS.0b013e3181fbe2bf.
  7. Godman, Cassandra A., et al. “Hyperbaric Oxygen Treatment Induces Antioxidant Gene Expression.” Annals of the New York Academy of Sciences, vol. 1197, June 2010, pp. 178–83. PubMed, doi:10.1111/j.1749-6632.2009.05393.x.
  8. Sun, Lei, et al. “Effect of Hyperbaric Oxygen Therapy on HMGB1/NF-ΚB Expression and Prognosis of Acute Spinal Cord Injury: A Randomized Clinical Trial.” Neuroscience Letters, vol. 692, 23 2019, pp. 47–52. PubMed, doi:10.1016/j.neulet.2018.10.059.
  9. Liu, Su, et al. “Hyperbaric Oxygen Alleviates the Inflammatory Response Induced by LPS Through Inhibition of NF-ΚB/MAPKs-CCL2/CXCL1 Signaling Pathway in Cultured Astrocytes.” Inflammation, vol. 41, no. 6, Dec. 2018, pp. 2003–11. PubMed, doi:10.1007/s10753-018-0843-2.
  10. Meng, Xiang-En, et al. “Hyperbaric Oxygen Alleviates Secondary Brain Injury After Trauma Through Inhibition of TLR4/NF-ΚB Signaling Pathway.” Medical Science Monitor, vol. 22, International Scientific Information, Inc., Jan. 2016, pp. 284–88. www.medscimonit.com, doi:10.12659/MSM.894148.
  11. Sweeney, Susan E., and Gary S. Firestein. “Rheumatoid Arthritis: Regulation of Synovial Inflammation.” The International Journal of Biochemistry & Cell Biology, vol. 36, no. 3, Mar. 2004, pp. 372–78. ScienceDirect, doi:10.1016/S1357-2725(03)00259-0.
  12. Slade, John B., et al. “Pain Improvement in Rheumatoid Arthritis with Hyperbaric Oxygen: Report of Three Cases.” Undersea & Hyperbaric Medicine: Journal of the Undersea and Hyperbaric Medical Society, Inc, vol. 43, no. 4, Aug. 2016, pp. 467–72.
  13. Dantzer, Robert. “Neuroimmune Interactions: From the Brain to the Immune System and Vice Versa.” Physiological reviews vol. 98,1 (2018): 477-504. doi:10.1152/physrev.00039.2016
  14. Blaskovits, Farriss1; Tyerman, Jane1; Luctkar-Flude, Marian2,3 Effectiveness of neurofeedback therapy for anxiety and stress in adults living with a chronic illness: a systematic review protocol, JBI Database of Systematic Reviews and Implementation Reports: July 2017 – Volume 15 – Issue 7 – p 1765-1769 doi: 10.11124/JBISRIR-2016-003118
  15. Mateen, Somaiya et al. “Increased Reactive Oxygen Species Formation and Oxidative Stress in Rheumatoid Arthritis.” PloS one vol. 11,4 e0152925. 4 Apr. 2016
  16. Mikirova, N., Rogers, A., Casciari, J. and Taylor, P. (2012) Effect of high dose intravenous ascorbic acid on the level of inflammation in patients with rheumatoid arthritis. Modern Research in Inflammation, 1, 26-32. doi: 10.4236/mri.2012.12004.
  17. Arosio, Enrico et al. “Forearm haemodynamics, arterial stiffness and microcirculatory reactivity in rheumatoid arthritis.” Journal of hypertension vol. 25,6 (2007): 1273-8. doi:10.1097/HJH.0b013e3280b0157e
  18. Ganesan, Kalaivani et al. “Low frequency pulsed electromagnetic field–a viable alternative therapy for arthritis.” Indian journal of experimental biology vol. 47,12 (2009): 939-48prot