Depression

Major depressive disorder (MDD) is one of the most common mood disorders in the United States. Although there are many possible symptoms, depression is typically characterized by persistent feelings of sadness, hopelessness, and loss of motivation(1). The treatment of depression is incredibly important both for the health of your body, and the quality of your life.
 
Currently, the main treatment for depression is a combination of antidepressants and psychotherapy (“talk-therapy”). Unfortunately, about only 20% of depressed individuals experience symptom improvement with antidepressant medication(2). We highly recommend neurofeedback therapy for depression, especially for those who do not respond well to conventional treatment, or those looking for a a therapy with long-lasting benefits.

 

Extivita Therapies for Depression:

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Extivita Therapies Depression:

Hyperbaric Oxygen Therapy for Depression

Hyperbaric Oxygen Therapy

Neurofeedback Therapy for Depression

Neurofeedback

Supplements for Depression

Supplements

Nutritional IV Therapy for Depression

Nutritional IV Therapy

Hyperbaric Oxygen Therapy for Depression:

Hyperbaric Oxygen Therapy - Chapel Hill
Hyperbaric oxygen therapy (HBOT) may help relieve the symptoms of depression by decreasing levels of inflammation. Although the exact pathophysiology of depression remains unknown, research suggests that it involves elevated levels of pro-inflammatory markers in both the peripheral body and the central nervous system (brain and spinal cord)(3-4).

 

Additionally, studies have successfully decreased depressive symptoms using anti-inflammatory medication (5). HBOT has proven anti-inflammatory effects, giving it strong potential as a low-risk therapy for those with depression(6-9).

Decreases Inflammation

Decreased Inflammation

Neurofeedback for Depression:

Neurofeedback protocols for depression typically focus on increasing brain activity in the left frontal lobe(10). Many people with depression have elevated alpha (8-12Hz) activity in the left frontal lobe, which can suppress faster brain waves necessary for increased brain activation(10). The left frontal lobe is associated with positive emotions and approach behavior, so a decrease of activity here can cause a person to focus less on positive emotions and more on negative emotions and withdrawal behavior(11-12). While decreasing left frontal alpha is the most common protocol for depression, neurofeedback protocol will be based heavily on one’s qEEG brain map, behavioral assessment, and neurofeedback consultation.

Common EEG Abnormalities in Depression:

  • More alpha (8-12Hz) activity in the left frontal lobe compared to the right frontal lobe(3)
  • Increased theta to beta ratio in the frontal lobe(3)
Learn more about Neurofeedback

IV Therapy for Depression:

We recommend the Myer’s Cocktail IV and Glutathione IV for depression due to their antioxidant effects, as well as the NAD+ IV due to its protective effects on DNA and mitochondria. Oxidative stress, which causes cellular damage and inflammation, is known to be increased in those with depression(13-15). Vitamin C (a major component of the Myer’s Cocktail IV) and Glutathione are both powerful antioxidants that decrease levels of oxidative stress by eliminating reactive oxygen species(16-17). Additionally, low levels of Magnesium and certain B Vitamins (both of which are in the Myer’s Cocktail IV) have been associated with depression(18-21). Lastly, NAD+ has protective effects on DNA and mitochondria, both of which are likely damaged in those with depression(22-24).

Learn more about IV Therapy
Nutritional IV Therapy in Durham, NC

News & Research for Depression:

Targeting vascular inflammation in ischemic stroke: Recent developments on novel immunomodulatory approaches.

Targeting vascular inflammation in ischemic stroke: Recent developments on novel immunomodulatory approaches.

May 14, 2018 |

Ischemic stroke is a devastating and debilitating medical condition with limited therapeutic options. However, accumulating evidence indicates a central role of inflammation in all aspects of stroke including its initiation, the progression of injury, and recovery or wound healing. A central target of inflammation is disruption of the blood brain barrier or neurovascular unit. Here we discuss recent developments in identifying potential molecular targets and immunomodulatory approaches to preserve or protect barrier function and limit infarct damage and functional impairment.

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The Effect of Hyperbaric Oxygen Therapy on Functional Impairments Caused by Ischemic Stroke.

The Effect of Hyperbaric Oxygen Therapy on Functional Impairments Caused by Ischemic Stroke.

May 3, 2018 |

While research suggests a benefit of hyperbaric oxygen therapy (HBOT) for neurologic injury, controlled clinical trials have not been able to clearly define the benefits. To investigate the effects of HBOT on physical and cognitive impairments resulting from an ischemic stroke. Using a within-subject design a baseline for current functional abilities was established over a 3-month period for all subjects (n=7). Each subject then received two 4-week periods of HBOT for a total of 40 90-minute treatments over a 12-week period. Subjects completed a battery of assessments and had blood drawn six times over the 9-month total duration of the study.

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Increased circulating endothelial progenitor cells and improved short-term outcomes in acute non-cardioembolic stroke after hyperbaric oxygen therapy.

Increased circulating endothelial progenitor cells and improved short-term outcomes in acute non-cardioembolic stroke after hyperbaric oxygen therapy.

Mar 29, 2018 |

Acute ischemic stroke is a leading cause of mortality and long-term disability, and profiles of endothelial progenitor cells (EPCs) reflect the degree of endothelial impairment. This study tested the hypothesis that hyperbaric oxygen therapy (HBOT) both improves the clinical short-term outcomes and increases the number of circulating EPCs and antioxidant capacity. The numbers of circulating EPCs [CD133/CD34 (%), KDR/CD34 (%)], biomarkers for oxidative stress (thiols and thiobarbituric acid-reactive substances), and clinical scores (National Institutes of Health Stroke Scale [NIHSS], Barthel index [BI],

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References
  1. NIMH » Depression. https://www.nimh.nih.gov/health/topics/depression/index.shtml. Accessed 19 Oct. 2020.
  2. Information, National Center for Biotechnology, et al. “Depression: How Effective Are Antidepressants?” InformedHealth.Org [Internet], Institute for Quality and Efficiency in Health Care (IQWiG), 2020. www.ncbi.nlm.nih.gov, https://www.ncbi.nlm.nih.gov/books/NBK361016/.
  3. Howren, M. Bryant, et al. “Associations of Depression with C-Reactive Protein, IL-1, and IL-6: A Meta-Analysis.” Psychosomatic Medicine, vol. 71, no. 2, Feb. 2009, pp. 171–86. PubMed, doi:10.1097/PSY.0b013e3181907c1b.
  4. Setiawan, Elaine, et al. “Role of Translocator Protein Density, a Marker of Neuroinflammation, in the Brain during Major Depressive Episodes.” JAMA Psychiatry, vol. 72, no. 3, Mar. 2015, pp. 268–75. PubMed, doi:10.1001/jamapsychiatry.2014.2427.
  5. Köhler, Ole, et al. “Effect of Anti-Inflammatory Treatment on Depression, Depressive Symptoms, and Adverse Effects: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.” JAMA Psychiatry, vol. 71, no. 12, Dec. 2014, pp. 1381–91. PubMed, doi:10.1001/jamapsychiatry.2014.1611.
  6. Benson, R. M., et al. “Hyperbaric Oxygen Inhibits Stimulus-Induced Proinflammatory Cytokine Synthesis by Human Blood-Derived Monocyte-Macrophages.” Clinical and Experimental Immunology, vol. 134, no. 1, Oct. 2003, pp. 57–62. PubMed Central, doi:10.1046/j.1365-2249.2003.02248.x.
  7. Lin, Kao-Chang, et al. “Attenuating Inflammation but Stimulating Both Angiogenesis and Neurogenesis Using Hyperbaric Oxygen in Rats with Traumatic Brain Injury.” The Journal of Trauma and Acute Care Surgery, vol. 72, no. 3, Mar. 2012, pp. 650–59. PubMed, doi:10.1097/TA.0b013e31823c575f.
  8. Godman, Cassandra A., et al. “Hyperbaric Oxygen Treatment Induces Antioxidant Gene Expression.” Annals of the New York Academy of Sciences, vol. 1197, June 2010, pp. 178–83. PubMed, doi:10.1111/j.1749-6632.2009.05393.x.
  9. Shapira, Ronit, et al. “Hyperbaric Oxygen Therapy Ameliorates Pathophysiology of 3xTg-AD Mouse Model by Attenuating Neuroinflammation.” Neurobiology of Aging, vol. 62, Feb. 2018, pp. 105–19. ScienceDirect, doi:10.1016/j.neurobiolaging.2017.10.007.
  10. Dias, Álvaro Machado, and Adrian van Deusen. “A New Neurofeedback Protocol for Depression.” The Spanish Journal of Psychology, vol. 14, no. 1, May 2011, pp. 374–84. DOI.org (Crossref), doi:10.5209/rev_SJOP.2011.v14.n1.34.
  11. Davidson, Richard J. “Affective Style and Affective Disorders: Perspectives from Affective Neuroscience.” Cognition and Emotion, vol. 12, no. 3, Routledge, May 1998, pp. 307–30. Taylor and Francis+NEJM, doi:10.1080/026999398379628.
  12. Hammond, D. Corydon. “Neurofeedback Treatment of Depression and Anxiety.” Journal of Adult Development, vol. 12, no. 2, Aug. 2005, pp. 131–37. Springer Link, doi:10.1007/s10804-005-7029-5.
  13. Bhatt, Shvetank, et al. “Role of Oxidative Stress in Depression.” Drug Discovery Today, vol. 25, no. 7, July 2020, pp. 1270–76. ScienceDirect, doi:10.1016/j.drudis.2020.05.001.
  14. Black, Catherine N., et al. “Is Depression Associated with Increased Oxidative Stress? A Systematic Review and Meta-Analysis.” Psychoneuroendocrinology, vol. 51, Jan. 2015, pp. 164–75. ScienceDirect, doi:10.1016/j.psyneuen.2014.09.025.
  15. Rawdin, B. J., et al. “Dysregulated Relationship of Inflammation and Oxidative Stress in Major Depression.” Brain, Behavior, and Immunity, vol. 31, July 2013, pp. 143–52. ScienceDirect, doi:10.1016/j.bbi.2012.11.011.
  16. Traber, Maret G., and Jan F. Stevens. “Vitamins C and E: Beneficial Effects from a Mechanistic Perspective.” Free Radical Biology & Medicine, vol. 51, no. 5, Sept. 2011, pp. 1000–13. PubMed Central, doi:10.1016/j.freeradbiomed.2011.05.017.
  17. Forman, Henry Jay, et al. “Glutathione: Overview of Its Protective Roles, Measurement, and Biosynthesis.” Molecular Aspects of Medicine, vol. 30, no. 1–2, 2009, pp. 1–12. PubMed Central, doi:10.1016/j.mam.2008.08.006.
  18. Tarleton, Emily K., and Benjamin Littenberg. “Magnesium Intake and Depression in Adults.” The Journal of the American Board of Family Medicine, vol. 28, no. 2, American Board of Family Medicine, Mar. 2015, pp. 249–56. www.jabfm.org, doi:10.3122/jabfm.2015.02.140176.
  19. Serefko, Anna, et al. “Magnesium and Depression.” Magnesium Research, vol. 29, no. 3, Sept. 2016, pp. 112–19. www.jle.com, doi:10.1684/mrh.2016.0407.
  20. Hvas, Anne-Mette, et al. “Vitamin B6 Level Is Associated with Symptoms of Depression.” Psychotherapy and Psychosomatics, vol. 73, no. 6, Karger Publishers, 2004, pp. 340–43. www.karger.com, doi:10.1159/000080386.
  21. Bell, Iris R., et al. “B Complex Vitamin Patterns in Geriatric and Young Adult Inpatients with Major Depression.” Journal of the American Geriatrics Society, vol. 39, no. 3, 1991, pp. 252–57. Wiley Online Library, doi:https://doi.org/10.1111/j.1532-5415.1991.tb01646.x.
  22. Increased 8-Hydroxy-Deoxyguanosine, a Marker of Oxidative Damage to DNA, in Major Depression and Myalgic Encephalomyelitis / Chronic Fatigue Syndrome – PubMed. https://pubmed.ncbi.nlm.nih.gov/20035260/. Accessed 12 Mar. 2021.
  23. Czarny, Piotr, et al. “Elevated Level of DNA Damage and Impaired Repair of Oxidative DNA Damage in Patients with Recurrent Depressive Disorder.” Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, vol. 21, Feb. 2015, pp. 412–18. PubMed Central, doi:10.12659/MSM.892317.
  24. Chang, Cheng-Chen, et al. “Mitochondria DNA Change and Oxidative Damage in Clinically Stable Patients with Major Depressive Disorder.” PLOS ONE, vol. 10, no. 5, Public Library of Science, May 2015, p. e0125855. PLoS Journals, doi:10.1371/journal.pone.0125855.