NAD + supplementation normalizes key Alzheimer’s features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency
Abstract Emerging findings suggest that compromised cellular bioenergetics and DNA repair contribute to the pathogenesis of Alzheimer's disease (AD), but their role in disease-defining pathology is unclear. We developed a DNA repair-deficient 3xTgAD/Polβ+/- mouse that...
Magnesium in Migraine Prophylaxis-Is There an Evidence-Based Rationale? A Systematic Review
Abstract Objective: The primary objective was to systematically evaluate the existing evidence base on magnesium in migraine prophylaxis. Methods: The search for clinical trials published from 1990 to 2016 was separately conducted by AvL and FR using standard search...
A diver with immersion pulmonary oedema and prolonged respiratory symptoms.
Abstract: Immersion pulmonary oedema (IPE) is particularly associated with an excessive reaction to exercise and/or cold stress. IPE usually resolves without recompression therapy within a day or two. Herein we report a diver diagnosed with IPE, in whom symptoms...
International Survey Regarding the Use of Rehabilitation Modalities in Horses.
Abstract: To define which biologic, electrophysical and other modalities are used in horses for injury or performance issues, a questionnaire regarding 38 modalities was distributed to eight veterinary groups. A total of 305 complete or partial responses were obtained...
Prevalence of augmented renal clearance and performance of glomerular filtration estimates in Indigenous Australian patients requiring intensive care admission.
Abstract: Augmented renal clearance (ARC) refers to the enhanced renal excretion of circulating solute commonly demonstrated in numerous critically ill subgroups. This study aimed to describe the prevalence of ARC in critically ill Indigenous Australian patients and...
Growth Hormone (GH) and Cardiovascular System
Abstract This review describes the positive effects of growth hormone (GH) on the cardiovascular system. We analyze why the vascular endothelium is a real internal secretion gland, whose inflammation is the first step for developing atherosclerosis, as well as the...
Hyperbaric oxygen treatment in thromboangiitis obliterans: a retrospective clinical audit.
Abstract: Wounds refractory to standard treatment in patients with thromboangiitis obliterans (TAO, Buerger's disease) are associated with amputation, other morbidity and mortality. The purpose of this study was to investigate the effect of hyperbaric oxygen treatment...
Efficacy of hyperbaric oxygen therapy in bacterial biofilm eradication.
Abstract: Chronic wounds typically require several concurrent therapies, such as debridement, pressure offloading, and systemic and/or topical antibiotics. The aim of this study was to examine the efficacy of hyperbaric oxygen therapy (HBOT) towards reducing or...
Hyperbaric oxygen therapy of air embolus in the cerebral venous sinuses after intracranial surgery: a case report.
Abstract: A case with cerebral venous air embolism (CVAE) after neurosurgery and treated with hyperbaric oxygen therapy (HBOT) is presented. This is a rare and potentially fatal complication that neurosurgeons should be aware of. A 52-year-old male was diagnosed with...