Abstract:
A literature review did not reveal any controlled study on the management of necrotizing fasciitis. Treatment protocol includes: – an immediate or early surgical management with debridement of all necrotic tissue and extensive fasciotomy followed by a surgical reexamination of the infected area in the following days; – an initial antibiotic therapy targeting aerobic Gram-positive and Gram-negative organisms and anaerobes (e.g: amoxicilline-clavulanic acid or vancomycin-metronidazole); – an adequate nutritional support, infusion, and resuscitation; – hyperbaric oxygen therapy may be considered as an associated treatment; but there is no randomized, controlled trial demonstrating its efficacy.
Derancourt, , , , , , , , (2001). [Management of necrotizing cellulitis and fasciitis]. Annales de dermatologie et de venereologie, 2001 Mar;128(3 Pt 2):452-7. https://www.ncbi.nlm.nih.gov/pubmed/11319377